Hollow Microneedle Technology
Take Drug Delivery to New Levels
Hollow microneedle technology from 3M offers exciting benefits for difficult-to-deliver biologics. Differentiate your product with 3M™ Hollow Microstructured Transdermal System for intradermal delivery of biologics. 3M Hollow Microstructured Transdermal System offers reproducible intradermal delivery, and provides a patient-friendly design based on human factors testing and voice-of-customer research.
3M recently completed a human tolerability study with the goal of selecting the appropriate microneedle array for use in clinical studies. The outcome of this study found very good delivery times for 2 mL (less than 2 minutes on average). Additionally, the clinical study results provide foundational data in assessing the safety of the device. Clinical supplies are now available for assessment in potential development partners' trials.1
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Improve Patient Experience
Millions of people require injectable treatments, but an estimated 10% avoid treatment due to needle phobia. 3M hollow microneedle technology is designed for efficient delivery of liquid formulations into the skin via a 1 cm2 hollow microneedle array. This approach has been found to be less intimidating in human factors and primary market research studies.2
The 3M™ Hollow Microstructured Transdermal System has been created with patients in mind. This single-use delivery system designed for self-administration provides many patient-friendly features such as a textured grip for dexterity-challenged patients, a protective safety cap for the microneedle array, and an audible click for added assurance of actuation and a status indicator window with a progress bar.
By potentially reducing anxiety, microneedle delivery may improve patient compliance in some patient groups.
Reproducible Intradermal Delivery
A growing number of companies working with biologics, are looking for new delivery methods to meet these products' unique formulation requirements. 3M Hollow Microstructured Transdermal System offers reproducible delivery of liquid formulations into the dermis. With a hollow microneedle length of 1500 micron combined with flexibility to deliver from 0.5 mL to 2 mL over a range of viscosities, 3M Hollow Microstructured Transdermal System provides an intradermal delivery option for your valuable biologic formulation.
Steps to Clinical Readiness
In leading up to the finalized 3M Hollow Microstructured Transdermal System design. 3M has applied a rigorous process including:
- conducting a human tolerability study
- finalizing the device design
- manufacturing critical components from medical grade materials
- establishing GMP array manufacturing and device assembly
- filing documentation with FDA
Expand the Range of Deliverable Biologics2
While drug PK profiles need to be evaluated on an individual basis, microneedle delivery via 3M™ Hollow Microstructured Delivery System may offer potential benefits when compared with conventional injections:
- Faster absorption
- Higher bioavailability of drugs
- Higher peak blood levels
- Reproducible intradermal delivery
- Intradermal administration of larger volumes (0.5 mL to 2 mL) over a range of viscosities
Stay at the Leading Edge
Gain a competitive edge when you partner with the expert in microneedle technology. For over 50 years, 3M has created innovative solutions for the pharmaceutical industry. Our product development and manufacturing specialists will work with you from start to finish, to create a hollow microneedle solution that gives you a competitive edge.
- Expertise in customizing solutions to fit drug formulation needs
- Secure supply chain with regulatory, global compliance & toxicology support from world class laboratories
- Dedicated process technology center to mitigate production risk when transferring complex products
- Start-to-finish services to develop & commercialize your innovation
- Global manufacturing capabilities that cover everything from clinical trials to full-scale commercial production and distribution
- Design based on human factors studies for dexterity-challenged patients
Learn about our clinical data findings, and discover how hollow microneedle technology and 3M can help you meet your strategic goals. Contact Us to learn more or request a sample of 3M hMTS demo device3
Related Posters, Presentations and Publications
Innovative Drug Delivery Technology to Meet Evolving Need of Biologics & Small Molecules (3.58 MB, PDF)
Three Steps to Your Feasibility Study (557.07 kb, PDF)
3M Hollow Microneedle System Brochure (776.52 kb, PDF)
Hollow Microneedle Delivery - Innovation Pointing the Way (1,181 kb, PDF)
3M Drug Delivery Systems - Intradermal Delivery of Biologics
Patient Demand, Vaccines, And Drug Delivery: Q&A With Steve Wick Of 3M Drug Delivery Systems
1 Initiation of clinical studies may require a submission for regulatory review
23M, data on file.
3 Disclaimer: representative models for demonstration purposes only. Not for sales or distribution. Not approved for in vitro or in vivo use. Initiation of clinical studies may require a submission for regulatory review.