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Reduce gum redness, swelling and bleeding with Peridex oral rinse


Prescription-strength Peridex™ oral rinse reduces bacteria in the mouth. Available only from your dentist, Peridex oral rinse is used to treat gingivitis, or inflammation of the gums. Your dentist may prescribe Peridex oral rinse if your gums are swollen and red, or if you notice bleeding when you brush or floss your teeth.

Have a prescription for Peridex oral rinse? Fill it on


As part of your daily brushing and flossing routine, Peridex oral rinse offers protection that helps:

  • Decrease bacteria in the mouth
  • Reduce gum redness and swelling
  • Control gum bleeding
  • Protect against gingivitis with prescription strength

Answers to Common Questions

How long should I use Peridex oral rinse?

Most patients use Peridex oral rinse for a short time, typically 1-2 weeks. However, your dentist may recommend that you use the product for a longer time based on your unique situation.

How is Peridex oral rinse different from mouthwash that I can buy without a prescription at my drugstore?

Peridex oral rinse contains the prescription-strength ingredient chlorhexidine gluconate. This ingredient is only available through your dentist or doctor. Chlorhexidine gluconate has years of clinical study and experience showing effective antimicrobial activity (in other words, it destroys or inhibits the growth of microorganisms).

Does Peridex oral rinse come in different flavors?

Peridex oral rinse comes in a mint flavor. At this time, there are no other flavors. Some people think that it has a medicinal taste. To decrease this, do not rinse your mouth with water or mouthwash after using Peridex oral rinse. Most people find that the medicinal taste becomes less noticeable with continued use of Peridex oral rinse.

When should I brush my teeth during use of Peridex oral rinse?

Brush your teeth before rinsing with Peridex oral rinse.

Are there risks to using Peridex oral rinse if I'm pregnant?

Please check with your dentist and doctor before using the product if you are pregnant.

I heard that Peridex oral rinse stains teeth – is that true? How can I prevent that?

Peridex oral rinse can cause temporary staining of the teeth. To minimize this, brush and floss daily, paying attention to areas where you notice discoloration. Stains can be removed by your dental professional during a usual tooth cleaning.

Are there any other side effects with this medication?

  • Some patients notice an increase in tartar build-up on their teeth, particularly on restored teeth. Tartar can be removed by your dental professional during a usual tooth cleaning.
  • Rarely, patients may notice a change in taste perception. If you notice this, contact your dentist.

Your dentist has prescribed Peridex™ (Chlorhexidine Gluconate 0.12%) Oral Rinse to treat your gingivitis, to help reduce the redness and swelling of your gums, and also to help you control any gum bleeding. Use Peridex regularly, as directed by your dentist, in addition to daily brushing. Spit out after use. Peridex should not be swallowed.

If you develop allergic symptoms such as skin rash, itch, generalized swelling, breathing difficulties, light headedness, rapid heart rate, upset stomach or diarrhea, seek medical attention immediately. Peridex should not be used by persons who have a sensitivity to it or its components.

Peridex may cause some tooth discoloration or increase in tartar (calculus) formation, particularly in areas where stain and tartar usually form. It is important to see your dentist for removal of any stain or tartar at least every six months or more frequently if your dentist advises.

  • Both stain and tartar can be removed by your dentist or hygienist. Peridex may cause permanent discoloration of some front-tooth fillings.
  • To minimize discoloration, you should brush and floss daily, emphasizing areas which begin to discolor.
  • Peridex may taste bitter to some patients and can affect how foods and beverages taste. This will become less noticeable in most cases with continued use of Peridex.
  • To avoid taste interference, rinse with Peridex after meals. Do not rinse with water or other mouthwashes immediately after rinsing with Peridex.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

The clinical significance of Peridex oral rinse’s antimicrobial activities is not clear. Three months after Peridex oral rinse use was discontinued, the number of bacteria in plaque had returned to baseline levels and resistance of plaque bacteria to chlorhexidine gluconate was equal to that at baseline.

Peridex oral rinse is indicated for use between dental visits as part of a professional program for the treatment of gingivitis. Patients with a known sensitivity to chlorhexidine gluconate should not use Peridex oral rinse. The effect of Peridex oral rinse on periodontitis has not been determined. Common side effects associated with the use of Peridex oral rinse include an increase in the staining of oral surfaces, an increase in calculus formation and an alteration in taste perception. Please see full prescribing information provided with the product.

For more information, see the prescribing information for Peridex oral rinse