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Sorbent Information for SDB-XC

SDB-XC is a poly(styrenedivinylbenzene) copolymer used as a reversed phase sorbent for solid phase extraction. SDB-XC is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked. It does not exhibit the secondary cationic (silanol) interactions and pH limitations common to bonded silica sorbents, so it offers more predictable and reproducible reversed phase interaction.

SDB-XC may be substituted into methods that use C18 or C8 bonded silica and often demonstrates greater capacity. The structure of SDB-XC provides unique selectivity, especially in the retention of moderately polar, water-soluble analytes. However, since SDB-XC displays both aromatic and aliphatic interactions and does not display secondary cationic attraction, some existing methods may require adjustment to optimize analyte retention and elution.

Comparison of Typical Silica and Copolymer Sorbents
  Silica Copolymer
pH Stability 2 to 12 1 to 14
% Organic < 22%* 100%
Secondary Interactions Yes No
Functionality Aliphatic Aromatic and aliphatic
Particle Shape Irregular Spherical
Pore Size 60 Å 80 Å
* varies from about 6% to 22% carbon, depending on functional group attached

 

Bioanalytical Applications

  • glucuronide metabolites
  • opiates
  • stimulants
  • antidepressants
  • antiarrhythmics
  • anticonvulsants
  • antibiotics
  • antihypertensives
  • benzodiazepines
  • moderately polar, water-soluble analytes
  

Chemical Structure

C18C18FFC8 Chemical Structure

 

EPA Approved Methods

  • 515.2 Chlorinated Acids
  • 526.1 Selected Semi-Volatile Organics
  • 8041 Phenols
  • 8081 Organochlorine Pesticide Leachate
  • 8270 Semi-Volatile Organic Compounds - TCLP Leachate
  • 8321 Phenoxyacid Herbicides - TCLP Leachate
  • 8330 Nitroaromatics and Nitroamines
  
Nominal Sorbent Properties
Sorbent: Poly(styrenedivinylbenzene)
Surface Area: 450 m²/g
Particle Size: 16 µm
Pore Size: 80 Å

Empore™ SDB-XC Extraction Disk Cartridges

These products contain small, densely packed particles. Proper use requires higher vacuum or pressure than with other SPE products. When used with a vacuum manifold, typically >15 in Hg (0.51 bar) is needed to pass solutions through the disk cartridge.
3M Addresses