Sorbent Information for SDB-RPS

SDB-RPS is a poly(styrenedivinylbenzene) copolymer that has been modified with sulfonic acid groups to make it hydrophilic. SDB-RPS is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked. The sulfonation imparts unique selectivity for organic analytes that are polar in nature, such as drugs, drug metabolites, water-soluble pesticides and pesticide metabolites. SDB-RPS is also useful for comprehensive drug screening, in which a wide range of analytes are simultaneously extracted. Although SDB-RPS is sulfonated, it has much lower capacity than a typical strong cation exchanger. Because SDB-RPS displays reversed phase and cation exchange interactions, both functionalities can be considered for designing selective extractions. SDB-RPS can be used as a reversed phase sorbent and substituted into existing methods. Organic analytes with polar character have been shown to extract better on SDB-RPS than on traditional C18 bonded silica. However, new dimensions in selectivity and elution can be achieved by considering the influence of the sulfonic acid groups to provide some cation exchange affinity for amine-containing analytes.

Applications Drugs and metabolites pesticides and metabolites drugs of abuse explosives polar organic compounds amine-containing analytes

Chemical Structure

Empore™ SDB-RPS Extraction Disk Cartridges

These products contain small, densely packed particles. Proper use requires higher vacuum or pressure than with other SPE products. When used with a vacuum manifold, typically >15 in Hg (0.51 bar) is needed to pass solutions through the disk cartridge.