At 3M, we are advancing the global biopharmaceutical industry by helping to build better and more efficient manufacturing processes, improving product safety by providing tools for monitoring and tracking, and reducing energy usage with our technologies.
Designed to achieve high product purity early in the manufacturing process workflow through chromatography, improving efficiency and economics.
Reduces the load on chromatography columns with a single-use product
Provides high fluid purity as early as possible in the downstream process
Provides the expensive protein A column the best possible protection
Helps reduce the total cost of ownership by simplifying the process train
Zeta Plus™ Encapsulated System
Single-Use Solutions for Cell Culture Clarification
3M offers a complete package of single-use systems for cell culture clarification applications for biopharmaceutical customers. Single-use Zeta Plus™ Encapsulated depth filter clarification solutions are available in scaleable capsule formats from R&D to process development to pilot / clinical production to commercial and large scale production.
LifeASSURE™ PDA Series Filters — The Preferred Membrane For Biopharmaceutical Applications
In addition to sterile filtration prior to the final filling step, sterilizing filters are used in many intermediate steps to reduce cross-contamination risk from in-process liquids such as buffers. Since biopharmaceutical unit operations are discontinuous in nature, elution pools (e.g. Protein A pool) need to be filtered with 0.2 µm filters prior to storage in order to manage bioburden loads. To prevent growth of microorganisms in downstream chromatography steps, post depth filter permeate is filtered using 0.2 µm sterilizing or bioburden reduction grade filters.